Basal cell adenoma misdiagnosed as an adenoid cystic. Superficial bcc is another common variant of bcc 1. Primary cutaneous adenoid cystic carcinoma pcacc is a very rare malignancy. Learn more about them here, including their signs and.
A case of cystic basal cell carcinoma which shows a. Basal cell carcinoma bcc constitutes 65% of epithelial tumours. Two different cell populations is an important clue for. We report a case of adenoid basal carcinoma of the uterine cervix discovered incidentally in a 69yearold woman who had been hysterectomized due to endometrial adenocarcinoma of the uterine corpus. Basal cell carcinoma bcc is almost exclusively seen in headneck region with rare involvement of trunk and extremities. Adenoid type of bcc is one of the rare histopathological types of bcc which has not found to have any site predilection.
Basal cell carcinoma bcc is the most common skin cancer in the white population 1. Here, we report a case of cystic basal cell carcinoma, which is relatively rare and might be clinically misdiagnosed. Adenoid basal cell carcinoma is a rare type of bcc. Cervical adenoid basal tumors comprised of adenoid basal. Artefactual separation of cells forming the nests from the underlying stroma key feature. Our dermatology online brief report sstudy of basal cell. The determination of the precise frequency with which these socalled abcs show. We report a case of multiple adenoid basal cell carcinomas at unusual sites in a middleaged male patient. The treatment may also depend upon the stage, overall health, age, and patternconfiguration of the tumor. The epithelial proliferations that are designated adenoid basal carcinoma abc in the current classification from the world health organization represent report. Adenoid basal carcinoma is thought to be derived from the multipotential basal or reserve. The indolent clinical course and an excellent prognosis unique to.
While the histology of this lesion is mostly predictable, some of the rare histological variants such as cystic, adenoid, morpheaform. What are the risk factors for adenoid basal carcinoma of uterine cervix. To our knowledge, this is the first report of such malignant. Jan 14, 2020 beneath the secretory lining is a layer of basal cells as well as interspersed endocrine. While the histology of this lesion is mostly predictable, some of the rare histological variants such as cystic, adenoid, morpheaform, infundibulocystic, pigmented and miscellaneous variants clearcell, signet ring. Clinical features of reported cases of adenoid type of basal cell carcinoma bcc on histopathology click here to view histopathology of this rare variant shows arrangement of cells in the intertwining strands and radially around islands of connective tissue, resulting in a tumour with a lace like pattern. Multinodular, basaloid cells in clusters, some with punched out lumens. Basal cell carcinoma bcc is the most common skin cancer in humans, which typically appears over the sunexposed skin as a slow growing, locally invasive lesion that rarely metastasizes. We studied 29 cases of basal cell carcinoma of the prostate including what others call adenoid cystic carcinoma of the prostate. Out of all basal cell carcinomas, giant basal cell carcinoma represents less than 1%. A combination of surgery, chemotherapy, and radiation therapy are used to treat basal cell adenocarcinoma of salivary gland. Basal cell carcinoma bcc is the most common type of skin cancer, thus numerous therapeutic approaches have been developed. Of 14 potential cases of lowgrade adenoid basal tumor associated with additional types of invasive carcinoma, 10 retrievable cases 9 consultation cases and 1 routine case were identified.
Many skin cancers can be removed quickly and easily using a simple surgical procedure, and often no additional treatment is needed. Histologic mimics of basal cell carcinoma archives of pathology. Superficial basal cell carcinoma, formerly referred to insitu basal cell carcinoma, is characterized by a superficial proliferation of neoplastic basal cells. Optimal treatment outcome should comprise complete removal of the tumor to the margin of normal tissue with the best possible aesthetic result. It occurs mainly in adults, in the head and neck area, primarily on the face. A the superficial parotid layer of the parotid gland. In the 100 cases with adenoid cystic carcinoma, there were 71 female and 29 male patients. Basal cell carcinoma bcc is the most common human malignant neoplasm and is. Yoneta a, horimoto k, nakahashi k, mori s, maeda k, yamashita t. Their recognition is important particularly when the component tumours have different biological behaviours. Basal cell carcinoma bcc is the most common malignant neoplasm, with an estimated overall lifetime risk of 30% in the united states. Surrounding fibromyxoid stroma, squamous differentiation, merges with basal cell hyperplasia.
Basal cell and adenoid cystic carcinoma basicmedical key. A dermatoscopic examination of the case revealed a homogenous blueblack area usually not seen in bcc. Clinical features of reported cases of adenoid type of basal cell carcinoma bcc on histopathology open in a separate window histopathology of this rare variant shows arrangement of cells in the intertwining strands and radially around islands of connective tissue, resulting in a tumour with a lace like pattern. Summary of reported cases of adenoid basal cell carcinoma with varied clinical presentations. It is a locally destructive tumour with varied clinical and histological appearances. Adenoid cystic carcinoma acc is primarily recognized as malignant neoplasm of the major and minor salivary glands, it may also infrequently arise from a variety of other rare sites specially those having mucous glands, like respiratory tract, external auditory canal, breast, lacrimal gland, uterus, vulva, cervix, prostate, thymus, skin, and esophagus 1,2. Adenoid basal carcinoma of the uterine cervix, first distinguished from adenoid cystic carcinoma by baggish and woodruff in 1966, accounts for less than 1% of all cervical adenocarcinomas. Nodular basal cell carcinoma hematoxylin and eosin, 20. Seborrheic keratosis sk is a common benign tumor in which malignancies like melanoma and nonmelanoma skin cancers nmscs can arise rarely. Adenoid squamous cell carcinoma definition of adenoid. It is more prevalent after the fourth decade of life and its peak incidence is at the 6 th decade with male preponderance. The key feature of basal cell carcinoma at low power magnification is of a basaloid epithelial tumour arising from the.
Carcinomas of the sweat glands do not possess a characteristic. Adenoid acantholytic squamous cell carcinoma request pdf. Ultraviolet b exposure is a significant factor in the development of basal cell and squamous cell carci noma. The expression of 3 basal reserve cell in adenoid basal carcinoma. Every year, close to 10 million people get diagnosed with bcc worldwide. Jun 07, 2019 basal cell carcinoma bcc is the most common malignant skin tumor which occurs more frequently over the sun exposed parts of body. Adenoid basal carcinoma of the uterine cervix is rare and its cell origin is still obscure.
Icd03 seer sitehistology validation list june 18, 2019 10. Basal cell carcinoma bcc is a slow progressing nonmelanocytic skin cancer that arises from basal cells ie, small, round cells found in the lower layer of the epidermis. A morphologic variant of basal cell carcinoma whcih consists of strands of basaloid cells in a reticulate pattern, which often has prominent stromal mucin and may coexist with solidtype basal cell carcinoma. Basal cell adenoma misdiagnosed as an adenoid cystic carcinoma in the parotid gland 315 no evidence of infiltrating margin. Use of cytology in the diagnosis of basal cell carcinoma. Jul 07, 2016 basal cell and adenoid cystic carcinoma rafael e. May 10, 2018 how is basal cell adenocarcinoma of salivary gland treated. Distinction of basaloid carcinoma of the prostate from benign basal cell lesions by using immunohistochemistry for bcl2 and ki67. Basal cell carcinoma can broadly be divided into three groups, based on the growth patterns. Its adenoid variant is a rare histological subtype. The most common methods of diagnosis was transurethral resection turp n29 and needle biopsy n9. A the superficial parotid layer of the parotid gland was removed, and the mass was excised. Adenoid basal carcinoma abc is a rare cervical malignancy accounting for less than 1% of all cervical cancers. Amin, md key facts terminology malignant neoplasm composed primarily of basaloid cells arising putatively from prostatic basal cells clinical issues wide age range 2889 years, but majority occur in older men most commonly presents with obstructive urinary symptoms normal.
Histologic mimics of basal cell carcinoma archives of. Basal cell carcinoma, adenoid type definition of basal. Basal cell carcinoma bcc is a common, locally invasive epithelial malignancy of skin and its appendages. Pdf adenoid basal cell carcinoma and its mimics researchgate. The prognosis and outcomes differ greatly and a correct histological diagnosis is vital in the management of these cases. Besides histomorphological clues, immunohistochemistry studies are very helpful in the. It is exclusively seen on sun exposed and hair bearing skin especially of the face. This tumor is generally responsive to topic chemotherapy, such as imiquimod, or fluorouracil. Immunohistochemistry is a helpful adjunct, although not imperative, if histological differences are conclusive. Sex distribution of basal cell carcinoma sex number of cases percentage males 12 57. Only 10% of all basal cell carcinomas are located on the trunk and majority is located on the head and neck. Diagnosis and treatment of basal cell and squamous cell. Basal cell carcinoma bcc is the most common form of nonmelanoma skin cancer occurring in the skin.
Jan 31, 2019 a 67yearoldwoman with a history of basal cell carcinoma bcc and actinic keratosis presented with an asymptomatic lesion on her central forehead for the preceding 3 months. Adenoid variant of basal cell carcinoma medwin publishers. Dermatopathologists might see a couple in their career. Tumors with a similar histopathological picture are cutaneous adenoid cystic carcinoma and primary cutaneous cribriform apocrine carcinoma.
A search of the english literature since the first description reveals only 33 cases,59. Basal cell carcinoma, abbreviated bcc, is an extremely common form of skin cancer. Basal cell carcinoma, adenoid type definition of basal cell. Squamous cell carcinoma insitu and basal cell carcinoma. Histopathological examination of the excised nodule revealed a tumour composed of basaloid cells with an adenoid pattern of growth.
Adenoid basal cell carcinoma a rare variant and a mimic. Adenoid cystic carcinoma is the most common malignant tumor of minor salivary glands occurring in the oral cavity and tongue. It shares the histologic pattern of adenoid cystic carcinoma, and can be differentiated with the help of characteristic histologic features. Further variant morphologies that may be seen in bcc include clear cell change, signet ring cells, granular cells, adamantinomatoids, adenoid. Site wise distribution of basal cell carcinoma site number of cases percentage head and neck eye lid 6 28. Synchronous adenoid cystic variant of basal cell carcinoma in the right lumbar region. Adenoid variant, basal cell carcinoma, cutaneous adenoid cystic carcinoma. The treatment of basal cell carcinoma depends on the size of the cancer and where it is located. Histopathology images of adenoid cystic carcinoma, tongue by. Hybrid tumours of the salivary gland are rare neoplasms that have been described only in the parotid and palate. These lesions may be associated, and occasionally show morphologic transitions with, conventional cervical malignancies. A case report of a rare histopathological subtype with dermoscopic aspects.
Beneath the secretory lining is a layer of basal cells as well as interspersed endocrine. It is characterized by nests of basaloid cells that extend from the epidermis, with neoplastic cells that resemble primordial germ cells. However, histopathology remains the gold standard for bcc subtyping 58. Primary basal cell carcinoma of the prostate with concurrent. Cervical adenoid basal carcinoma associated with invasive.
Generally, all racial and ethnic groups are at risk and the cancer is observed worldwide. Histopathology images of adenoid cystic carcinoma, tongue. Histopathology of this rare variant of basal cell carcinoma with eccrine differentiation adenoid shows arrangement of cells in the intertwining strands and radially around islands table 1. While the histology of this lesion is mostly predictable, some of the rare histological variants such as cystic, adenoid, morpheaform, infundibulocystic, pigmented and miscellaneous variants clear cell, signet ring. Adenoid basal carcinoma of uterine cervix is a rare form of cervical cancer. The differential diagnosis of pcaccs in pathology practice can be difficult and a group of primary and metastatic lesions, including adenoid basal cell carcinoma of the skin, should be considered in the differential diagnosis. Adenoid cystic carcinoma, tongue adenoid cystic carcinoma, tongue. Jan 17, 2006 basal cell carcinoma bcc, first described by jacob in 1827, 1 is the most common malignant neoplasm of humans. Their recognition is important particularly when the. A case of cystic basal cell carcinoma which shows a homogenous blueblack area under dermatoscopy. May be associated with minor component of usual type prostatic adenocarcinoma. The tumour is commonly seen on nose, eyelids, at the inner canthus of eyes and behind the ears.
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